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KMID : 0882420120820020164
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Korean Journal of Medicine
2012 Volume.82 No. 2 p.164 ~ p.169
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The Effect of Stress on Gastrointestinal Physiology in Irritable Bowel Syndrome
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Park Jung-Ho
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Abstract
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Stress is an acute threat to the homeostasis of an organism by events in the outside world and evokes adaptive responses to preserve the stability of the internal environment. This adaptation can be carried out by means of alterations in HPA axis hormones, the autonomic nervous system, metabolic and immune systems. However, chronic stress can lead to changes in adaptation system and cause a functional disease such as irritable bowel syndrome (IBS). In fact, stress plays an important role in the development and exacerbations of IBS symptoms and it has been postulated that stress have an effect on the pathophysiology of IBS, including an increase in visceral perception, alterations in gastrointestinal motility and increased intestinal permeability. Therefore, Therapeutic approaches targeting stress management could be of great benefit for patients with irritable bowel syndrome.
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KEYWORD
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Stress, Irritable bowel syndrome, Permeability, Motility, Hypersensitivity
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